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Fostemsavir Tris (BMS-663068 Tris) 是一种 HIV-1附着抑制剂。
Fostemsavir Tris (BMS-663068 Tris) 是一种 HIV-1附着抑制剂。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 553 | 现货 | |
5 mg | ¥ 1,490 | 现货 | |
10 mg | ¥ 2,150 | 现货 | |
25 mg | ¥ 3,650 | 现货 | |
50 mg | ¥ 5,130 | 现货 | |
100 mg | ¥ 6,880 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 2,290 | 现货 |
产品描述 | Fostemsavir Tris (BMS-663068 Tris) is the prodrug of BMS-626529,is a oral, safe and effective inhibitor of HIV-1 attachment. It inhibits human immunodeficiency virus type 1 (HIV-1) infection by binding to gp120 and interfering with the attachment of virus to CD4+ T-cells. |
体内活性 | BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells.The activity of BMS-626529 is virus dependent, due to heterogeneity within gp120.?BMS-626529 had half-maximal effective concentration (EC(50)) values of <10 nM against the vast majority of viral isolates;?however, susceptibility varied by >6 log(10), with half-maximal effective concentration values in the low pM range against the most susceptible viruses.?The in vitro antiviral activity of BMS-626529 was generally not associated with either tropism or subtype, with few exceptions.?Measurement of the binding affinity of BMS-626529 for purified gp120 suggests that a contributory factor to its inhibitory potency may be a relatively long dissociative half-life.? |
别名 | BMS-663068 Tris |
分子量 | 704.62 |
分子式 | C29H37N8O11P |
CAS No. | 864953-39-9 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 125 mg/mL (177.40 mM), Sonication is recommended. H2O: 100 mg/mL (141.92 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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